According to National Institute of Health, Typical antipsychotic drugs act on the dopaminergic system, blocking the dopamine type 2 (D2) receptors. Atypical antipsychotics have lower affinity and occupancy for the dopaminergic receptors, and a high degree of occupancy of the serotoninergic receptors 5-HT2A.
In addition, Typical Antipsychotic mostly ends with the "ZINES", atypical mostly ends with the "DONES" and the "PINES".
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